Determination and stress studies on YK-1101, a potential histone deacetylase, by HPLC–UV and HPLC–TOF/MS methods
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چکیده
منابع مشابه
Determination and stress studies on YK-1101, a potential histone deacetylase, by HPLC–UV and HPLC–TOF/MS methods
YK-1101, with its structure as S-((E)-4-((7S,10S,Z)-4-ethylidene-7-isopropyl-2,5,8,12-tetraoxo -9-oxa-16-thia-3,6,13,18-tetraazabicyclo[13.2.1]octadeca-1(17),15(18)-dien-10-yl)but-3-en-1-yl) ethanethioate, is synthesized as a potential histone deacetylase inhibitor. Its quality and stability under various stress conditions are not fully understood. In this study, a high performance liquid chrom...
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Clinical studies of histone deacetylase inhibitors.
Over the last 5 years, a plethora of histone deacetylase inhibitors (HDACi) have been evaluated in clinical trials. These drugs have in common the ability to hyperacetylate both histone and nonhistone targets, resulting in a variety of effects on cancer cells, their microenvironment, and immune responses. To date, responses with single agent HDACi have been predominantly observed in advanced he...
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ژورنال
عنوان ژورنال: Journal of Pharmaceutical Analysis
سال: 2013
ISSN: 2095-1779
DOI: 10.1016/j.jpha.2013.01.003